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Moreover, the indole core is substituted at R3 that has a carbonyl group and that is also bonded into a napthalene moeity. Napthalene is often a bicyclic composition of two fused benzene rings. This carbonyl bridge of JWH-018 classifies it as a ketone. JWH-018 is undoubtedly an analog of THJ-018, wherein the core indazole construction is substitute